<p><strong>产品属性 Product Attributes </strong></p> <p><strong>基本信息 </strong></p> 别名： Programmed cell death protein 1;hPD-1;PDCD1;CD279<br/>规格: 10ug ; 50ug ; 500ug ; 1mg<br/>外观(性状)： Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.2.<br/>纯度: ≥95% as determined by reducing SDS-PAGE.<br/>储存条件: Powder:＜-20℃ for long store;RT，3 weeks.Liquid:4-7℃，2-7 days;＜-20℃，3 months.<br/>运输条件： The product is shipped at ambient temperature.<p><strong>产品信息 </strong></p> 背景说明： Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain.PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators.PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1，IL-4，IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway.In addition，coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer.PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance，and thus contributes to the prevention of autoimmune diseases.As a cell surface molecule，PDCD1 regulates the adaptive immune response.Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation，cytokine production，and cytolytic function.<br/>来源： Human cells<p><strong>其它标识</strong></p> 溶剂: Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in ddH2O.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.<br/>内毒素: Less than 0.1 ng/ug(1 IEU/ug)as determined by LAL test. <p><strong>产品介绍 Product Introduction</strong></p> Recombinant Human Programmed Cell Death Protein 1 is produced by our Mammalian expression system and the target gene encoding Leu25-Gln167 is expressed with a 6His tag at the C-terminus. <p><strong>注意事项 Considerations</strong></p> 1.本产品仅供科研使用。请勿用于医药、临床诊断或治疗，食品及化妆品等用途。请勿存放于普通住宅区。 <br/>2.为了您的安全和健康，请穿好实验服并佩戴一次性手套和口罩操作。 <br/>3.实验结果可由多种因素影响，相关处理只限于产品本身，不涉及其他赔偿。